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Int J Biol Macromol ; 254(Pt 1): 127729, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38287566

RESUMO

Facemasks play a significant role as personal protective equipment during the COVID-19 pandemic, but their longevity is limited by the easy dissipation of electrostatic charge and the accumulation of bacteria. In this study, nanofibrous membranes composed of polyacrylonitrile and chitosan biguanide hydrochloride (PAN@CGH) with remarkable antibacterial characteristics were prepared through the coaxial electrospinning process. Particulate matter could be efficiently captured by the fibrous membrane, up to 98 % or more, via polarity-dominated forces derived from cyano and amino groups. As compared commercial N95 masks, the PAN@CGH was more resistant to a wider variety of disinfection protocols. Additionally, the nanofibrous membrane could kill >99.99 % of both Escherichia coli and Staphylococcus aureus. Based on these characteristics, PAN@CGH nanofibrous membrane was applied to facial mask, which possessed an excellent and long-lasting effect on the capture of airborne particles. This work may be one of the most promising strategies on designing high-performance face masks for public health protection.


Assuntos
Quitosana , Nanofibras , Humanos , Quitosana/farmacologia , Biguanidas/farmacologia , Pandemias , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Escherichia coli , Filtração
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